Weight-loss surgery may be a quick solution for some people as diabetes, some studies have suggested, and now researchers are getting closer to an explanation of why that might be the case. And it is much more than weight loss.
Researchers at Columbia University and Duke University studied two groups of obese diabetic patients in a hospital in New York. Ten people have a type of gastric bypass surgery substantially reduces the size of the stomach, and 11 people were on a strict diet. People in both groups lost 22-26 pounds average.
Scientists have measured and evaluated the circulating amino acids and acyl carnitines in the blood of subjects - Studies in animals have suggested that they might be related to insulin resistance. (Amino acids are the building blocks of proteins, acyl carnitines are fatty acids that are required to carnitine). And in fact, found a significant reduction of the "branched chain" amino acids within one month among patients who had weight loss surgery. But even after two months, patients on dietary intervention had little or no change in the very-branched-chain amino acids. This story WebMD offers a portrait of the most comprehensive research.
In essence, the lower the concentration of branched chain amino acids, insulin-resistant patients were less, the researchers reported online Wednesday in Science Translational Medicine. They replicated their results in a small group of obese patients at Duke and found the branched-chain amino acid levels were still lower after six months, among those who had gastric bypass surgery.
In short, something of surgery, not the weight loss itself, seems to be to improve glycemic control - and-amino acid levels seem to play a role. But it is unclear whether the amino acids cause less insulin resistance. Two cardiologists at Massachusetts General Hospital, writing in a related perspective:
"Further work is needed to determine whether the reduction in circulating concentrations of amino acids after the weight loss is the cause or the consequence of improvements in insulin sensitivity."
But safe to say, the research adds a growing consensus that the benefits of gastric bypass surgery should be further explored.
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